The domain within your query sequence starts at position 401 and ends at position 540; the E-value for the 3a1a domain shown below is 8e-55.
SRERMASEVTNNKGNLEDRCLSCGKKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQ SYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGAGTAEDAKLQEPWSCYMCLPQRCHGV LRRRKDWNMRLQDFFTTDPD